Spiropiperidine compounds as ligands for orl-1 receptor

Details Spiropiperidine compounds as ligands for orl-1 receptor Spiropiperidine compounds as ligands for orl-1 receptor

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01) C07D 471/10 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2450550

A compound of the formula (I) or a salt, prodrug or solvate thereof, wherein R1 and R2 groups are all hydrogen; A is a benzofuzed azahetero ring; W1-W2 is CH2-CH2; X1-X1 is CH2-CH2; and Z is methylene or carbonyl; or the like, is a ligand for ORL1-receptor and are useful for treating or preventing pain, a CNS disorder or the like in mammalian subjects.

L'invention concerne un composé de la formule (I) ou un sel, un prodrogue ou un solvate de ce dernier. Dans la formule (I), les groupes R?1¿ et R?2¿ représentent tous de l'hydrogène; A représente une combinaison cyclique azahétéro benzocondensée; W?1¿-W?2¿ représente CH¿2?-CH¿2?; X?1¿-X?1¿ représente CH¿2?-CH¿2?; et Z représente méthylène ou carbonyle; ou équivalent. Ce composé est un ligand du récepteur ORL1 et est utile pour le traitement ou la prévention des douleurs, d'un trouble du système nerveux central ou équivalent chez les mammifères.

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