Spiropiperidine derivatives as melanocortin receptor agonists

Details Spiropiperidine derivatives as melanocortin receptor agonists Spiropiperidine derivatives as melanocortin receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/496 (2006.01) A61P 15/00 (2006.01) A61P 15/10 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2403631

Certain novel spiropiperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Selon l'invention, certains nouveaux dérivés de spiropipéridine sont des agonistes du (des) récepteur(s) de la mélanocortine humaine et, en particulier, des agonistes sélectifs du récepteur de la mélanocortine 4 humaine (MC-4R). Ils sont donc utiles pour le traitement, le contrôle ou la prévention de maladies et de troubles sensibles à l'activation de MC-4R, tels que l'obésité, le diabète, la dysfonction sexuelle (y compris la dysérection et la dysfonction sexuelle chez la femme).

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