C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/02 (2006.01) C12N 15/62 (2006.01) A61K 39/00 (2006.01) C12N 7/04 (2006.01)
Patent
CA 2662707
Disclosed are split-core carrier substances which, as separate polypeptides, have the core N domain and the core C domain of the core protein of a hepatitis B virus and at least one foreign molecule against which an immune response is to be induced. According to the invention, the foreign molecule, especially the heterologous foreign amino acid sequence, is fused to the C terminus of the core N domain or to the N terminus of the core C domain and the core protein can form capsid-like particles. The invention also relates to the associated production method.
L'invention concerne des supports à noyaux fendus, qui, en tant que polypeptides séparés, présentent le domaine de noyau N et de noyau C de la protéine de noyau d'un virus de l'hépatite B et au moins une molécule étrangère, contre laquelle une réponse immunitaire doit être induite. Selon l'invention, la molécule étrangère, notamment la séquence d'acides aminés étrangère hétérologue est fusionnée à l'extrémité C du domaine de noyau N ou à l'extrémité N du domaine de noyau C et la protéine noyau peut former des particules de type capsides. L'invention concerne également leur procédé de fabrication.
Nassal Michael
Skamel Claudia
Walker Andreas
Goudreau Gage Dubuc
Universitatsklinikum Freiburg
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