Spoil protein and nucleic acid molecules and uses therefor

Details Spoil protein and nucleic acid molecules and uses therefor Spoil protein and nucleic acid molecules and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/54 (2006.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01) C12N 15/24 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2318727

Novel SPOIL polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length SPOIL proteins, the invention further provides isolated SPOIL fusion proteins, antigenic peptides and anti-SPOIL antibodies. The invention also provides SPOIL nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a SPOIL gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne des protéines, des molécules d'acide nucléique et des polypeptides SPOIL nouveaux. Outre les protéines SPOIL pleine longueur isolées, l'invention concerne aussi des peptides antigéniques, des protéines de fusion isolées SPOIL et des anticorps anti-SPOIL. L'invention porte aussi sur des molécules d'acide nucléique SPOIL, sur des vecteurs d'expression contenant une molécule d'acide nucléique de l'invention, sur des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et sur des animaux transgéniques dans lesquels un gène SPOIL à été introduit ou interrompu. Des procédés de diagnostic, de criblage et des procédés thérapeutiques dans lesquels les compositions de l'invention sont utilisées, sont également décrits.

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