Spontaneous emulsions containing cyclosporine

Details Spontaneous emulsions containing cyclosporine Spontaneous emulsions containing cyclosporine

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 38/12 (2006.01) A61K 38/13 (2006.01) A61K 9/00 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2458448

A pharmaceutical composition contains cyclosporine as the active ingredient. More specifically, the composition is an orally administered pharmaceutical formulation in the form of a spontaneous emulsion comprising cyclosporine, ethanol ethyl oleate and polyoxyethylene glycerol trioleate. A method for preparing an orally administered pharmaceutical composition involves first dissolving cyclosporine in ethanol. Polyoxyethylene glycerol trioleate and an oil component are then added, mixed and diluted in an aqueous media to form a spontaneous emulsion.

L'invention concerne une composition pharmaceutique contenant de la cyclosporine comme ingrédient actif. De manière plus spécifique, cette composition peut être administrée par voie orale sous forme d'une émulsion spontanée comprenant de la cyclosporine, de l'éthanol éthyle oléate et du polyoxyéthylène glycérole trioléate. L'invention traite d'un procédé de préparation d'une composition pharmaceutique administrée par voie orale qui consiste à faire dissoudre tout d'abord de la cyclosporine dans de l'éthanol. On ajoute ensuite du polyoxyéthylène glycérole trioléate et un composant d'huile, avant de les mélanger et de les diluer dans un milieu aqueux pour former une émulsion spontanée.

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