Spontaneous forming ellipsoidal phospholipid unilamellar...

A - Human Necessities – 61 – K

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A61K 9/127 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2666953

The instant invention relates generally to compositions and methods useful for the spontaneous formation of liposomes wherein the composition comprises anionic long chain lipids in combination with short chain lipids and a prosaposin-derived protein or polypeptide. The liposomes may be useful for treatment of disease, via administration of the liposome alone or in combination with additional therapeutic agents.

La présente invention concerne généralement des compositions et des procédés utiles pour la formation spontanée de liposomes, la composition comprenant des lipides à longue chaîne anioniques en combinaison avec des lipides à chaîne courte et une protéine ou un polypeptide dérivé(e) de la prosaposine. Les liposomes peuvent être utiles pour le traitement de la maladie, au moyen de l'administration du liposome seul ou en combinaison avec des agents thérapeutiques supplémentaires.

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