Sppls as modifiers of the p53 pathway and methods of use

Details Sppls as modifiers of the p53 pathway and methods of use Sppls as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2528084

Human SPPL genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPPL are provided.

L'invention concerne des gènes humains SPPL qui sont identifiés en tant que modulateurs de la voie p53, et sont par conséquent des cibles thérapeutiques des troubles associés à la fonction p53 défectueuse. L'invention porte aussi sur des procédés d'identification de modulateurs de p53 comprenant le criblage d'agents qui modulent l'activité de SPPL.

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