Spray drying of pharmaceutical formulations containing amino...

A - Human Necessities – 61 – K

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A61K 38/47 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 38/11 (2006.01) A61K 38/23 (2006.01) A61K 38/27 (2006.01) A61K 38/28 (2006.01)

Patent

CA 2319514

Methods of forming solid pharmaceutical compositions comprise solubilizing water-soluble polymers and amino acid-based components having molecular weights ranging from about 100 daltons to about 200,000 daltons or pharmaceutically acceptable salts thereof in solvents; and separating the solvents from the water-soluble polymers and the amino acid-based components or pharmaceutically acceptable salts thereof to form solid pharmaceutical compositions comprising the water-soluble polymers and the amino acid-based components or pharmaceutically acceptable salts thereof.

L'invention concerne des procédés permettant de former des compositions pharmaceutiques solides. Ces procédés consistent à dissoudre des polymères solubles à l'eau et des composants à base d'acides aminés dont le poids moléculaire se situe entre 100 daltons et 200000 daltons environ ou des sels pharmaceutiquement acceptables de ces derniers dans des solvants, puis à séparer les solvants des polymères solubles à l'eau et des composants à base d'acides aminés ou des sels pharmaceutiquement acceptables de ces derniers, pour former des compositions pharmaceutiques solides contenant les polymères solubles à l'eau et les composant à base d'acides aminés ou les sels pharmaceutiquement acceptables de ces derniers.

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