Spray drying of thrombin inhibitors

Details Spray drying of thrombin inhibitors Spray drying of thrombin inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61P 7/02 (2006.01) C07K 1/14 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2373068

The invention relates to a method for producing thrombin inhibitors which have a constant weight and which are of formula (I), whereby n represents 0, 1, 2 and tautomers thereof, whereby an aqueous solution of the active substance is spray dried.

L'invention concerne un procédé permettant de préparer des inhibiteurs de thrombinine de poids constant de la formule (I), n valant 0, 1, 2, ainsi que leurs tautomères. Selon ce procédé, une solution aqueuse du principe actif est séchée par pulvérisation.

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