Src kinase inhibitor compounds

Details Src kinase inhibitor compounds Src kinase inhibitor compounds

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/506 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2376951

Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogenesis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.

L'invention concerne des composés de pyrimidine (formule I), ou leurs sels acceptables pharmaceutiquement, des hydrates, des solvates, des formes de cristaux et des diastéréomères individuels, et des compositions pharmaceutiques contenant ceux-ci, qui sont des inhibiteurs des enzymes de tyrosine kinase, et qui en tant que tels sont utiles à la prophylaxie et au traitement de troubles liés à la protéine tyrosine kinase, tels que des maladies immunologiques, des troubles hyperprolifératifs et d'autres troubles. Dans ces maladies, l'action inappropriée de la protéine kinase est censée jouer un rôle, comme le cancer, l'angiogénèse, l'athérosclérose, le rejet de greffe, l'arthrite rhumatoïde et le psoriasis.

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