Srik a novel cell cycle protein associated with rip3

Details Srik a novel cell cycle protein associated with rip3 Srik a novel cell cycle protein associated with rip3

C - Chemistry, Metallurgy

12

N

C12N 9/12 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2389430

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

La présente invention concerne de nouveaux polypeptides, acides nucléiques et molécules liées qui possèdent un effet sur le cycle cellulaire ou sont liées à celui-ci. L'invention se rapporte également à des vecteurs et à des cellules hôtes renfermant ces séquences nucléotidiques, à des molécules de polypeptides chimères renfermant les polypeptides de l'invention fusionnés avec des séquences de polypeptides hétérologues, à des anticorps qui se lient aux polypeptides de l'invention et à des procédés de production des polypeptides de l'invention. L'invention concerne en outre des procédés permettant d'identifier de nouvelles compositions qui interviennent comme médiateurs dans la bioactivité du cycle cellulaire, et l'utilisation de ces compositions dans le diagnostic et le traitement de maladies.

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