C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/05 (2006.01) A61K 38/17 (2006.01) A61P 31/18 (2006.01) A61P 31/22 (2006.01) A61P 37/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2409414
The invention concerns a novel SSA-56kDA polypeptide and its fragments, cDNA cloning and polynucleotides encoding said polypeptides, cloning and/or expression vectors including said polynucleotides, cells transformed by said vectors and specific antibodies directed against said polypeptides. The invention also concerns methods for detecting and/or assaying said polypeptides and polynucleotides, corresponding diagnostic kits, a method for screening ligands, a method for detecting anti-Ro/SSA-like autoantibodies, a method for purifying a human biological fluid capable of containing anti-Ro/SSA-like autoantibodies, and compounds for use as medicines for preventing and/or treating viral pathologies such as AIDS and autoimmune diseases, in particular systemic lupus erythematosus (SLE)and Sjögren syndrome.
La présente invention concerne un nouveau polypeptide SSA-56 kDa et ses fragments, le clonage de l'ADNc et les polynucléotides codant lesdits polypeptides, des vecteurs de clonage et/ou d'expression incluant lesdits polynucléotides, des cellules transformées par lesdits vecteurs et des anticorps spécifiques dirigés contre lesdits polypeptides. L'invention concerne également des procédés de détection et/ou de dosage desdits polypeptides et polynucléotides, les trousses de diagnostic correspondantes, un procédé de criblage de ligands, un procédé de détection d'auto-anticorps anti-Ro/SSA-like, un procédé de purification d'un fluide biologique humain susceptible de contenir des auto-anticorps anti-Ro/SSA-like, ainsi que des composés utilisables à titre de médicaments pour la prévention et/ou le traitement de pathologies virales telles que le SIDA et de maladies auto- immunes, notamment du lupus systémique érythémateux (SLE) et du syndrome de Sjögren.
Bahr Georges
Capron Andre
Cocude Cecile
Institut Pasteur de Lille
Istac
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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