Ssi tyrphostins and pharmaceutical compositions

Details Ssi tyrphostins and pharmaceutical compositions Ssi tyrphostins and pharmaceutical compositions

A - Human Necessities

61

K

A61K 31/275 (2006.01)

Patent

CA 2177289

SSI thyrphostins are useful in preventing LPS induced toxicity, TNF.alpha. induced toxicity, LPS induced increases in TNF.alpha. levels, nitric oxide production and the treatment of septic shock and various immune disorders. Featured are novel compounds and pharmaceutical compositions, both of which may be used in the methods of prevention and/or treatment described herein, as well as methods for making the novel compounds.

Les tyrphostines SSI sont utiles pour prévenir la toxicité produite par les lipopolysaccharides, la toxicité produite par le facteur de nécrose tumorale-.alpha., l'accroissement de la concentration du facteur de nécrose tumorale-.alpha. provoqué par les lipopolysaccharides, la production d'oxyde nitrique, et pour traiter le choc septique et divers dérèglements immunitaires. Sont décrits de nouveaux composés et compositions pharmaceutiques pouvant être utilisés dans les procédés de prévention et/ou de traitement précités, ainsi que des procédés pour fabriquer ces nouveaux composés.

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