Ssl7 mutants and uses therefor

Details Ssl7 mutants and uses therefor Ssl7 mutants and uses therefor

C - Chemistry, Metallurgy

07

K

C07K 14/31 (2006.01) C07K 1/22 (2006.01) C07K 14/47 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2667636

The invention relates to SSL7 mutants which have no, or at least reduced, ability to bind to IgA. The mutants have significant application in the purification or isolation of C5 from samples and in the identification or detection, including quantitation, of C5 in samples. Use of the mutants has the benefit of minimising or preventing simultaneous isolation and/or detection of IgA in a sample, simplifying and improving methods relying on wild type SSL7.

Cette invention concerne des mutants SSL7 ne présentant aucune ou peu de capacité à se lier à IgA. Ces mutants peuvent être tout particulièrement utilisés pour purifier ou isoler C5 à partir d'échantillons, et pour identifier, détecter et même quantifier C5 dans des échantillons. L'utilisation des mutants présente l'avantage de réduire ou de prévenir l'isolement et/ou la détection de IgA dans un échantillon, de simplifier et d'améliorer les procédés reposant sur le SSL7 de type sauvage.

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