Stabile isotonic lyophilized protein formulation

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/26 (2006.01) A61K 9/08 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2745743

A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.

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