A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/26 (2006.01) A61K 9/08 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2745743
A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.
Andya James
Cleland Jeffrey L.
Hsu Chung C.
Lam Xanthe M.
Overcashier David E.
Genentech Inc.
Smart & Biggar
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