Stabilisation of glycosated t-pa

Details Stabilisation of glycosated t-pa Stabilisation of glycosated t-pa

A - Human Necessities

61

K

A61K 38/49 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/20 (2006.01) A61K 47/22 (2006.01) A61K 47/26 (2006.01) C12N 9/96 (2006.01)

Patent

CA 2046876

ABSTRACT The invention concerns a pharmaceutical preparation of a glycosylated protein with t-PA activity with an activity of a least 1.4 MU/ml and a pH value of 4.5 to 9, which contains citrate and at least one compound from the group consisting of a) ascorbic acid, b) EDTA, c) amino compounds of the formula R1R2N - R - X whereby X = SO3H, H, NH2 or OH, R = C1-C9- alkylene, C3-C6-cycloalkylene or benzylidene and R1 and R2, independently of one another, are H or C1-C3-alkyl, d) guanidinobutyric acid, e) dimethylbiguanide, f) 7-aminoheptanoic acid, 8-aminooctanoic acid, p-aminomethylbenzoic acid, .delta.-aminovaleric acid, .gamma.-aminobutyric acid, g) glucosamine, fructose, h) pyrimidine nucleosides and pyrimidine nucleotides, i) malic acid, lactic acid, fumaric acid or 2-oxo- glutaric acid, as well as a medicament based on a glycosylated protein with t-PA activity and processes for its preparation.

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