A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/02 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) C12N 15/68 (2006.01)
Patent
CA 2423307
The invention relates to a vaccine comprising a pharmaceutically acceptable carrier or diluent and a bacterium, wherein the bacterium contains (i) a DNA sequence encoding a site-specific recombinase, and (ii) a plasmid comprising a recognition element for the recombinase and a DNA sequence encoding a heterologous polypeptide. The recombinase stabilises inheritance of the plasmid and thereby prevents the bacterium from losing the ability to express the heterologous polypeptide.
La présente invention concerne un vaccin comprenant un excipient ou diluant pharmaceutiquement acceptable et une bactérie, ladite bactérie comprenant (i) une séquence d'ADN codant pour une recombinase site-spécifique et (ii) un plasmide comprenant un élément de reconnaissance de la recombinase et une séquence d'ADN codant pour un polypeptide hétérologue. La recombinase permet de stabiliser l'hérédité du plasmide et ainsi d'éviter à la bactérie de perdre son aptitude à exprimer le polypeptide hétérologue.
Stephens Jonathan Clive
Turner Arthur Keith
Acambis Research Limited
Macrae & Co.
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