A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/04 (2006.01)
Patent
CA 2590620
The present invention relates to stabilised 99mTc radiopharmaceutical compositions of the ligand tetrofosmin, which include an ascorbic acid or ascorbate radioprotectant, in the absence of an antimicrobial preservative. The invention also provides lyophilised kits suitable for the bulk preparation of multiple unit patient doses of 99mTc-tetrofosmin metal complexes. Also disclosed are unit doses of 99mTc-tetrofosmin, together with processes for preparing such unit doses from the lyophilised bulk vial.
La présente invention concerne des compositions radiopharmaceutiques stabilisées99mTc du ligand tetrofosmine, qui comprennent un radioprotecteur acide ascorbique ou ascorbate en l~absence d~un conservateur antimicrobien. Cette invention décrit également des kits lyophilisés convenant à la préparation en grandes quantités de doses patients à unités multiples de complexes métalliques à base de 99mTc-tetrofosmine. Cette invention décrit également des doses unitaires de 99mTc-tetrofosmine ainsi que des procédés de préparation de ces doses unitaires à partir de la fiole lyophilisée en vrac.
Hjelstuen Ole Kristian
Martinussen Grethe Karin
Stensrud Gry
Fetherstonhaugh & Co.
Ge Healthcare Limited
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