A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7105 (2006.01) A61K 38/00 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) A61K 39/145 (2006.01) A61P 31/00 (2006.01) A61P 31/16 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C12N 15/67 (2006.01)
Patent
CA 2457959
The invention relates to a pharmaceutical composition containing an mRNA which is stabilised by sequence modifications in the translated region and is optimised for the translation. The inventive pharmaceutical composition is especially suitable as a vaccine and as a therapeutic agent for tissue repair. The invention also relates to a method for determining sequence modifications used to stabilise mRNA and to optimise the translation of the same.
L'invention concerne une composition pharmaceutique qui contient un ARNm stabilisé par des modifications de séquence dans la région traduite et optimisé pour la traduction. La composition pharmaceutique selon l'invention convient notamment comme vaccin et comme agent thérapeutique pour la régénération tissulaire. L'invention concerne également un procédé servant à déterminer des modifications de séquence servant à la stabilisation et à l'optimisation en vue de la traduction d'ARNm.
Hoerr Ingmar
Pascolo Steve
von Der Muelbe Florian
Curevac Gmbh
Kirby Eades Gale Baker
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