Stabilised polymeric aerosols for pulmonary gene delivery

A - Human Necessities – 61 – K

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Details

A61K 9/12 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2437555

The use of non-viral delivery of therapeutically effective compositions through aerosol for therapy or research purpose has been limited by the low efficiency mainly caused by an inefficient delivery system and destruction of formulation (gene and/or delivery sytem) by aerosol shearing power. This invention develops formulations that are established polymer combination formulations. The formulations are highly efficient in delivering genes in vivo through aerosol and are able to protect the delivered gene from the destruction by aerosol shearing power.

L'utilisation de l'administration non virale de compositions efficaces au niveau thérapeutique au moyen d'aérosol, dans des buts thérapeutiques ou de recherche, a été limitée par la faible efficacité due principalement à un système d'administration inefficace et à la destruction de la préparation (gène et/ou système d'administration) par une force de cisaillement d'aérosol. Cette invention développe des préparations qui sont des préparations de combinaisons polymères établies. Ces préparations sont hautement efficaces dans l'administration de gènes <i>in vivo</i> au moyen d'aérosol et sont capables de protéger le gène administré de la destruction par une force de cisaillement d'aérosol.

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