A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/00 (2006.01) A61K 47/08 (2006.01) A61K 47/18 (2006.01) A61K 51/12 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2431660
The present invention relates to stabilised 99mTc radiopharmaceutical compositions, which include both a radioprotectant and one or more antimicrobial preservative(s), and hence have an extended lifetime of use. The radioprotectant is ascorbic acid, para -aminobenzoic acid, gentisic acid or a salt thereof with a biocompatible cation, and the antimicrobial preservative is one or more compound from the paraben series of preservatives. The invention is particularly useful for cationic, lipophilic 99mTc heart imaging agents such as MyoviewTM.
La présente invention a trait à des compositions radiopharmaceutiques? 99m¿Tc stabilisées, contenant à la fois un radioprotecteur et au moins un conservateur antimicrobien, ayant par conséquent une durée d'utilisation prolongée. Le radioprotecteur utilisé est un acide ascorbique, un acide para-aminobenzoïque, un acide gentisique ou un sel de ceux-ci comportant un cation biocompatible. Le conservateur antimicrobien utilisé est au moins un composé de la série parabène de conservateurs. L'invention est particulièrement utile pour des agents d'imagerie cardiaque? 99m¿Tc lipophiles, cationiques, tels que Myoview.TM..
Edwards David
Forster Alan Michael
Hjelstuen Ole Kristian
Amersham Plc
Fetherstonhaugh & Co.
Ge Healthcare Limited
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