Stability-enhanced variants of parathyroid hormone

Details Stability-enhanced variants of parathyroid hormone Stability-enhanced variants of parathyroid hormone

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/29 (2006.01) C07K 14/635 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2132949

2132949 9320203 PCTABS00027 Herein described are variants of parathyroid hormone that retain significant PTH activity and are substantially resistant to trypsin and trypsin-like enzymes. The variants are useful pharmaceutically, to treat bone disorders such as osteoporosis and in other therapeutic applications. Specific embodiments of the invention include [His25]PTH, [His26G1n27]PTH and [His25His26Leu27]PTH.

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