Stabilization of active agents by formulation into...

Details Stabilization of active agents by formulation into... Stabilization of active agents by formulation into...

A - Human Necessities

61

K

A61K 9/14 (2006.01)

Patent

CA 2460436

Methods for stabilizing active agents, particularly pharmaceutical agents, are described. The method comprises forming active agents into a nanoparticulate composition comprising the active agent and at least one surface stabilizer. The component active agent exhibits chemical stability, even following exposure to, for example, a prolonged storage period, an elevated temperature, light, radiation, radiation causing photolysis, non-physiological pH, enzymes or other catalysts, water or other solvent molecules, oxidizing agents or other free radicals, or freezing.

L'invention concerne des procédés de stabilisation d'agents actifs, notamment d'agents pharmaceutiques. Ce procédé consiste à préparer des agents actifs sous forme de composition nanoparticulaire contenant lesdits agents actifs et au moins un stabilisateur de surface. L'agent actif du composant présente une stabilité chimique qui résiste à l'exposition aux longues périodes de conservation, aux températures élevées, à la lumière, au rayonnement, au rayonnement entraînant la photolyse, au pH non physiologique, aux enzymes ou à d'autres catalyseurs, à l'eau ou à d'autres molécules solvantes, aux oxydants ou à d'autres radicaux libres, ou encore aux cycles de gel-dégel.

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