Stabilization of cardiac troponin

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/47 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2606333

The present invention relates to a troponin protein or complex of two troponin proteins stabilized in a matrix containing at least one anionic surfactant. The stabilized troponin or complex of troponin proteins is used as a control or calibration standard in assays for the determination of blood levels of troponin in patient samples that are expect to exhibit elevated levels of cardiac proteins. The troponin protein or complex of troponin proteins remains stabilized at room temperatures for at least six (6) months.

La présente invention concerne une protéine de type troponine ou un complexe de deux protéines de type troponines stabilisé(e) dans une matrice contenant au moins un tensioactif anionique. La protéine de type troponine stabilisée ou le complexe de protéines de type troponines stabilisé est utilisé(e) comme étalon de contrôle ou référence d'étalonnage dans des dosages permettant de déterminer des concentrations sanguines de troponine dans des prélèvements de patients supposés présenter des niveaux de protéines cardiaques élevés. A température ambiante, la protéine de type troponine ou le complexe de protéines de type troponines reste stable pendant au moins six (6) mois.

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