Stabilization of colloidal systems through the formation of...

Details Stabilization of colloidal systems through the formation of... Stabilization of colloidal systems through the formation of...

A - Human Necessities

61

K

A61K 47/36 (2006.01) A61K 9/00 (2006.01) A61K 9/10 (2006.01) A61K 9/107 (2006.01) A61K 9/51 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2195881

Stabilization of colloidals systems through the formation of ionic lipid- polisaccharide complexes. There is disclosed a process for the preparation of colloidal systems which includes the incorporation of a water soluble and positively charged amino polysaccharide and a negatively charged phospholipid. The colloidal systems (which comprise polymer nanoparticles, nanocapsules and nano-emulsions) are stabilized through the formation of a ionic complex, at the interface, comprised of the aminopolysaccharide and the phospholipid. The colloidal systems are characterized in that they have a particle size lower than 1 µm, an electric positive charge and an exeptional stability during storage. They are lyophilizable so that they can be dry stored and redispersed subsequently while maintaining the original characteristics of the system. They are useful as pharmaceutical forms for the oral, transdermic, topical, ocular, nasal and vaginal administration of medicaments. They are also useful as forms for cosmetic use.

Stabilisation de systèmes colloïdaux par formation de complexes ioniques lipides-polysaccharides. L'invention décrit un procédé de préparation de systèmes colloïdaux, qui consiste à incorporer une combinaison d'un aminopolysaccharide soluble dans l'eau et de charge positive et d'un phospholipide de charge négative. Les systèmes colloïdaux (comprenant les nanoémulsions, les nanocapsules et les nanoparticules polymères) sont stabilisés par la formation d'un complexe ionique, au niveau de l'interface, constitué par l'aminopolysaccharide et le phospholipide. Les systèmes colloïdaux se caractérisent en ce qu'ils présentent une taille de particule inférieure à 1 mu m, une charge électrique positive et une stabilité exceptionnelle pendant le stockage. Ils sont lyophilisables, ce qui permet leur conservation au sec et leur redispersion ultérieure, tout en gardant les caractéristiques d'origine du système. Ils offrent un intérêt en tant que formes pharmaceutiques pour l'administration orale, transdermique, topique, oculaire, nasale et vaginale de médicaments. De plus, ils présentent un intérêt en tant que formes à usage cosmétique.

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