C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/49 (2006.01) A61K 39/21 (2006.01) A61P 31/18 (2006.01) C07K 14/16 (2006.01) C12N 15/48 (2006.01)
Patent
CA 2305341
The present application is directed to stabilized envelope glycoprotein trimers. The trimers are stabilized by introducing disulfide bonds at certain sites in the gp41 ectodomain. DNA molecules encoding such trimers can be used to generate an immunogenic reaction.
La présente invention se rapporte à des glycoprotéines trimères d'enveloppe stabilisés. Ces trimères sont stabilisés par l'introduction de liaisons bisulfure dans certains sites de l'ectodomaine de gp41. On peut utiliser les molécules d'ADN codant ces trimères pour déclencher une réponse immunogénique.
Farzan Michael
Sodroski Joseph G.
Dana-Farber Cancer Institute Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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