Stabilization of helicobacter urease

Details Stabilization of helicobacter urease Stabilization of helicobacter urease

C - Chemistry, Metallurgy

12

P

C12P 21/06 (2006.01) A01N 37/18 (2006.01) C07K 1/00 (2006.01) C07K 14/205 (2006.01) C12N 9/78 (2006.01) C12N 9/80 (2006.01) C12N 9/96 (2006.01) C12N 9/99 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2303486

The invention provides methods for stabilizing recombinant Helicobacter urease by (i) contacting it with a compound that modifies an amino acid of the urease, or (ii) genetically modifying a urease amino acid. The stabilized urease is prevented from the molecular aggregation or activation (e.g., in vitro activation) characteristic of untreated urease.

L'invention concerne des procédés visant à stabiliser l'Helicobacter-uréase de recombinaison (i) en la mettant au contact d'un composé qui modifie un acide aminé de l'uréase, ou (ii) en modifiant génétiquement un acide aminé de l'uréase. L'uréase stabilisée est exempte de l'agrégation ou de l'activation moléculaire (par exemple, activation in vitro) caractéristique de l'uréase non traitée.

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