Stabilization of highly purified proteins

Details Stabilization of highly purified proteins Stabilization of highly purified proteins

C - Chemistry, Metallurgy

12

N

195/78, 530/3.18

C12N 9/96 (2006.01) A61K 38/00 (2006.01) A61K 47/26 (2006.01) A61K 47/36 (2006.01) C07K 1/16 (2006.01) C07K 14/755 (2006.01)

Patent

CA 2021452

PATENT CL-168 ABSTRACT OF THE DISCLOSURE A carbohydrate, such as mannitol or Dextran-70, is added during the purification of a protein, such as Factor VIII:C. The carbohydrate stabilizes the protein, even when the protein is 60-99% pure. The carbohydrate is added across various purification steps and is present in the final container so as to stabilize the protein during freeze-drying and reconstitution.

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