Stabilization of immunogens derived from paramyxoviruses

Details Stabilization of immunogens derived from paramyxoviruses Stabilization of immunogens derived from paramyxoviruses

A - Human Necessities

61

K

A61K 39/155 (2006.01) A61K 47/02 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2418939

Subunit non-adjuvanted immunogenic compositions of respiratory syncytial virus were stabilized by the formulation with various stabilizing agents including monosodium glutamate. The formulations retained protein conformation for at least 8 weeks at elevated temperatures.

Des compositions immunogènes dépourvues d'adjuvants de sous-unités du virus respiratoire syncytial ont été stabilisées du fait de la formulation avec divers agents de stabilisation comprenant le glutamate monosodique. Ces formulations ont conservé la conformation des protéines pendant au moins 8 semaines à des températures élevées.

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