Stabilization of implantable bioprosthetic tissue

Details Stabilization of implantable bioprosthetic tissue Stabilization of implantable bioprosthetic tissue

A - Human Necessities

61

L

A61L 27/36 (2006.01) A61L 27/50 (2006.01)

Patent

CA 2397263

The invention relates to implantable bioprostheses (e.g. implantable biological tissues) and to compositions and methods for stabilizing them. Implantable bioprostheses stabilized as described herein exhibit improved mechanical properties and reduced post-implantation calcification. The implantable bioprosthesis is made by contacting a bioprosthesis (e.g. a tissue obtained from an animal or an article comprising a tissue and a synthetic material) with a polyepoxy amine compound.

L'invention concerne des bioprothèses implantables, telles que des tissus biologiques implantables, ainsi que des compositions et des méthodes permettant de les stabiliser. Les bioprothèses implantables stabilisées de l'invention possèdent des propriétés mécaniques améliorées et entraînent une calcification postopératoire réduite. Ces bioprothèses implantables sont réalisées en mettant en contact une bioprothèse, telle qu'un tissu animal ou un article constitué d'un tissu et d'un matériau synthétique, avec un composé amine polyépoxyde.

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