Stabilization of interferon against mechanical stress

Details Stabilization of interferon against mechanical stress Stabilization of interferon against mechanical stress

C - Chemistry, Metallurgy

07

K

167/103.1, 530/1

C07K 14/565 (2006.01)

Patent

CA 1059029

Abstract of the Disclosure The present invention encompasses a method for stabilizing interferon during purification comprising treating an interferon preparation with an effective stabilizing amount of reduced glutathione, thiodiglycol, thioethanolamine, thioalkanoic acid having 1-7 carbon atoms, monothioglycerol, dithiotreitol, thiotic acid, N-acetylcysteine, or N-acetylhomocysteine as a sulfur containing reducing agent for selectively retaining interferon sulfhydryl groups in the reduced state. The method of the present invention preserves the activity of interferon by selectively retaining interferon sulfhydryl (-SH) functions in the reduced state without reducing interferon disulfide linkages (-S-S-) which are essential for activity.

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