Stabilization of intracellular enzymes

Details Stabilization of intracellular enzymes Stabilization of intracellular enzymes

C - Chemistry, Metallurgy

12

N

195/139, 195/34.

C12N 9/96 (2006.01) C12N 1/04 (2006.01) C12N 11/02 (2006.01) C12N 11/04 (2006.01) C12P 19/24 (2006.01)

Patent

CA 1267618

ABSTRACT The subject invention concerns a process for stabilizing intact or ruptured microbial cells having active enzymes associated therewith. Speci- fically exemplified is a process for stabilizing glucose isomerase producing cells of a microorganism belonging to the genus Ampullariella. In the inven- tion process the whole or ruptured microbial cells are contacted with a partially modified cationic polyelectrolyte, e.g., a partially modified polyamine, to stabilize and flocculate the cells. It is critical that the polyelectrolyte be partially modified; a fully modified or non-modified polyelectrolyte will not give the surprising beneficial results of the invention process. The flocculated cells are further stabilized by encapsulation with a partially modified cationic polyelectrolyte. The encapsulation can be done prior to or after the flocculated cells are cross-linked. The net effect is manifested by a dramatic increase in the half-life of the enzyme, thus leading to a more effective use of the immobilized enzyme.

501549

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