A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/26 (2006.01) A61K 38/37 (2006.01) A61K 47/02 (2006.01) C07K 1/02 (2006.01) A61K 9/08 (2006.01)
Patent
CA 2683317
The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of -56 °C or higher.
La présente invention a pour objet un procédé de stabilisation d'une solution en vrac d'une protéine recombinante pour un stockage à l'état congelé, qui comprend l'apport d'une solution partiellement purifiée de la protéine recombinante qui présente une concentration en sel monovalent d'au moins 100 mM et l'addition d'un glucide à ladite solution dans une quantité suffisante pour que, après congélation, la solution ait une température de transition vitreuse de -56 °C ou supérieure.
Desponds Arnaud
Joshi Omkar
Tsvetkova Nelly
Wang Deqian
Wu Paul
Bayer Healthcare Llc
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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