A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 31/5513 (2006.01)
Patent
CA 2659179
This invention relates to orally disintegrable, lorazepam-containing dosage forms which are storage stable and disintegrable within about 90 seconds or less. In one embodiment, there is provided a storage stable, orally disintegrable dosage form comprising: protected lorazepam particles comprising lorazepam and polymeric material having a glass transition temperature of about 65°C or above. Also disclosed is a method of producing a storage stable lorazepam containing tablet.
La présente invention a pour objet des formes de dosage contenant du lorazépam désintégrables oralement, stables au stockage et désintégrables en 90 secondes environ ou moins. Dans un mode de réalisation, une forme de dosage stable au stockage, désintégrable oralement comprend : des particules de lorazépam protégées comprenant du lorazépam et un matériel polymérique dont la température de transition vitreuse est d'environ 65 °C ou plus. L'invention concerne également une méthode permettant de produire un comprimé qui contient du lorazépam stable au stockage.
Bereuter Larry
Brown David K.
Moe Derek
Cima Labs Inc.
Goudreau Gage Dubuc
LandOfFree
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