A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/18 (2006.01)
Patent
CA 2540324
The present inventon relates to stable pharmaceutical protein formulations that are stabilized using peptide stabilizers selected from the gorup consisting of Gly-Gly, Gly-Gly-Gly, Gly-Tyr, Gly-Phe, Gly-His, Gly-Asp, Gly- Ala, Ala-Gly, Ala-Ala, derivatives thereof and mixtures thereof. Furthermore, the present invention relates to stable pharmaceutical formulations comprising erythropoietin and peptide stabilizers selected from dipeptides, tripepitides, tetrapeptides, pentapeptides, and mixtures thereof. In addition to peptide stabilizers, the formulations may contain surfactants.
La présente invention concerne des formulations de protéines pharmaceutiques stables qui sont stabilisées à l'aide de stabilisants peptidiques sélectionnés dans le groupe constitué de Gly-Gly, Gly-Gly-Gly, Gly-Tyr, Gly-Phe, Gly-His, Gly-Asp, Gly-Ala, Ala-Gly, Ala-Ala, de dérivés de ceux-ci et de mélanges de ceux-ci. Cette invention concerne également des formulations pharmaceutiques stables renfermant de l'érythropoïétine et des stabilisants peptidiques sélectionnés parmi des dipeptides, tripeptides, tétrapeptides, pentapeptides et des mélanges de ceux-ci. Outre les stabilisants peptidiques, ces formulations peuvent contenir des tensioactifs.
Faict Dirk
Somers Fabian
Baxter Healthcare S.a.
Baxter International Inc.
Sim & Mcburney
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