Stabilization of poly(oxyalkylene) containing polymeric...

C - Chemistry – Metallurgy – 08 – K

Patent

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C08K 5/09 (2006.01) A61L 27/00 (2006.01) A61L 27/18 (2006.01) A61L 31/00 (2006.01) C08G 18/50 (2006.01) C08G 18/66 (2006.01) C08G 18/71 (2006.01) C08K 5/00 (2006.01) C08K 5/098 (2006.01) C08L 71/02 (2006.01) C08L 75/14 (2006.01) C08K 3/32 (2006.01) C08K 5/092 (2006.01) C08K 5/17 (2006.01)

Patent

CA 2503529

The present invention provides a method for producing a medical device, preferably an ophthalmic device, more preferably a contact lens, made of a stabilized poly(oxyalkylene)containing polymeric material. The method of the invention comprises the steps of: curing, in a mold, a composition comprising (a) a prepolymer having at least one poly(oxyalkylene) unit, (b) a biocompatible organic multi-acid or biocompatible salt thereof in an amount sufficient to improve the stability of the poly(oxyalkylene)-containing polymer made from the composition, (c) optionally a photoinitiator or a thermal initiator, and (d) optionally one or more vinylic monomers, to form the medical device being less susceptible to oxidative degradation; and removing the medical device from the mold.

L'invention concerne un procédé de réalisation de dispositif médical, de préférence ophtalmique, et de préférence encore de lentille de contact, en matériau polymère contenant du poly(oxyalkylène) stabilisé. Les étapes du procédé sont les suivantes: traitement, dans un moule, d'une composition comprenant (a) un prépolymère ayant au moins une unité poly(oxyalkylène), (b) un sel biocompatible organique multi-acide ou biocompatible correspondant, en quantité suffisante pour améliorer la stabilité du polymère contenant le poly(oxyalkylène) résultant de la composition, (c) éventuellement un photo-initiateur ou un initiateur thermique, et (d) éventuellement un ou plusieurs monomères, puis extraction hors du moule. On réalise ainsi un dispositif médical moins exposé à la dégradation oxydative.

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