Stabilization of proteins by cationic biopolymers

A - Human Necessities – 61 – K

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A61K 47/30 (2006.01) A61K 9/16 (2006.01) A61K 9/22 (2006.01) A61K 9/52 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2099376

2099376 9211844 PCTABS00014 A method is described for the incorporation of proteins in the form of specific noncovalent complexes with polycationic reagents, into sustained release systems, where the polycation stabilizes the protein against inactivation while it resides in the delivery device, and retards release of the protein from the delivery device. Alternatively, the polycation-protein complex itself serves as a depot for release of the protein active agent, rather than a polymeric matrix. The end result is the release of the active agent with retention of biological activity, with a high cumulative field, over a sustained period of time.

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