A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/12 (2006.01) A61K 51/04 (2006.01)
Patent
CA 2703518
The invention relates to stabilised radiopharmaceutical compositions which comprise: (i) an 18F-labelled compound; (ii) an effective stabilizing amount of gentisic acid or a salt thereof with a biocompatible cation; (iii) an aqueous biocompatible carrier medium; wherein the radioactive concentration of the 18F in the carrier medium is in the range 10 to 100,000 MBq/ml and the pH of the composition is in the range 4.0 to 9.5. The invention further comprises methods for preparing such radiopharmaceutical compositions and a new use of gentisic acid or a salt thereof.
L'invention porte sur des compositions radiopharmaceutiques stabilisées qui comprennent : (i) un composé marqué par 18F ; (ii) une quantité stabilisante efficace d'acide gentisique ou d'un sel de celui-ci avec un cation biocompatible ; (iii) un milieu de support biocompatible aqueux, la concentration radioactive du 18F dans le milieu de support se situant dans la plage de 10 à 100 000 MBq/ml et le pH de la composition se situant dans la plage de 4,0 à 9,5. L'invention comprend en outre des procédés pour préparer de telles compositions radiopharmaceutiques et une nouvelle utilisation de l'acide gentisique ou d'un sel de celui-ci.
Van Den Bos Jan
Fetherstonhaugh & Co.
Ge Healthcare Bv
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