Stabilization of solid drug formulations

A - Human Necessities – 61 – K

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A61K 9/48 (2006.01) A61K 9/20 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2423574

Pharmaceutical formulations and dosage forms are provided having improved stability to moisture-induced degradation when compared with conventional dosage forms, especially tablets. The invention features low compression forms of drugs known to be susceptible to moisture-induced degradation together with excipients, preferably in encapsulated forms. In other embodiments, relatively non-volatile oils can be admixed with the drug and/or the excipients to stabilize the formulation toward moisture-induced degradation. Hydrophobic powders are also optionally added to the formulations.

L'invention concerne des formulations pharmaceutiques de posologies possédant une meilleure stabilité vis-à-vis de la dégradation causée par l'humidité lorsqu'on les compare à des posologies classiques et en particulier à des comprimés. L'invention concerne également des formes de compression basse de médicaments connus pour leur tendance à être dégradés par l'humidité ainsi que des excipients, de préférence sous forme de capsules. Selon d'autres modes de réalisation, des huiles relativement peu volatiles peuvent être ajoutées au médicament et/ou aux excipients afin de stabiliser la formulation par rapport à la dégradation causée par l'humidité. On peut éventuellement adjoindre des poudres hydrophobes auxdites formulations.

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