Stabilization of somatotropins and other proteins by...

Details Stabilization of somatotropins and other proteins by... Stabilization of somatotropins and other proteins by...

C - Chemistry, Metallurgy

07

K

C07K 1/107 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07C 233/18 (2006.01) C07C 237/22 (2006.01) C07K 14/55 (2006.01) C07K 14/61 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2041742

31,278-00 STABILIZATION OF SOMATOTROPINS AND OTHER PROTEINS BY MODIFICATION OF CYSTEINE RESIDUES ABSTRACT OF THE INVENTION The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing said derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.

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