C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/06 (2006.01) C12N 9/96 (2006.01) C12Q 1/28 (2006.01) C12Q 1/62 (2006.01)
Patent
CA 2068496
ABSTRACT This invention relates to a process for stabilizing the enzyme urate oxidase (commonly known as uricase) in liquid form, and to the relative compositions which can then be obtained, with particular reference to compositions containing a Trinder reagent. According to the process of the invention, uricase can be stabilized in liquid form by adding to the composition containing the enzyme a substituted or unsubstituted dicarboxylic acid containing from 2 to i carbon atoms, and preferably 4 or 5. Aspartic acid has shown to be particularly effective in providing said stabilizing activity in liquid uricase compositions containing a Trinder reagent.
D'alterio Maurizio
Frontini Dario
Papagni Mauro
Instrumentation Laboratory S.r.l.
Smart & Biggar
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