Stabilization process for biological cells and stabilized...

Details Stabilization process for biological cells and stabilized... Stabilization process for biological cells and stabilized...

A - Human Necessities

61

K

167/114, 195/34.

A61K 35/14 (2006.01) G01N 33/86 (2006.01)

Patent

CA 1193544

STABILIZATION PROCESS FOR BIOLOGICAL CELLS AND STABILIZED COMPOSITIONS THEREOF ABSTRACT OF THE DISCLOSURE Biological cell compositions are stabilized to preserve aldehyde functionality by formation of acetal, particularly cyclic acetal, primarily in order to prevent cell-to-cell crosslinking. The stabilized biological cells are particularly useful as human blood particle analogs in reference reagents employed in electronic hematology testing instrumentation. A process for preparing the acetal stabilized biological cells employs reaction of polyaldehyde-treated biological cells with alcohol, preferably including 1,2 dialcohol, under acidic conditions; thereafter, the resulting product solution is adjusted to basic condition, stabilizing the acetal formation on the biological cells. -1-

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