Stabilized alpha helical peptides and uses thereof

Details Stabilized alpha helical peptides and uses thereof Stabilized alpha helical peptides and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01)

Patent

CA 2544223

Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (~hydrocarbon stapling~) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.

L'invention concerne de nouveaux polypeptides et des méthodes de production et d'utilisation desdits polypeptides. Les polypeptides de l'invention comprennent des fragments de réticulation ("agrafage d'hydrocarbures") qui metten en oeuvre une attache entre deux fragments d'acide aminé, laquelle attache limite la structure secondaire du polypeptide. Les polypeptides de l'invention peuvent être utilisés pour traiter des maladies caractérisées par une mort cellulaire excessive ou inappropriée.

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