Stabilized aminophylline solution and process therefor

A - Human Necessities – 61 – K

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A61K 31/52 (2006.01) A61K 47/18 (2006.01) C07D 473/08 (2006.01)

Patent

CA 1084842

Abstract of the Disclosure A stable aqueous aminophylline solution is provided by admixing with said solution disodium edetate as a chelat- ing agent and removing substantially all the carbon dioxide from the solution. In a preferred manner the chelating agent is present in an amount of 0.01 to 1.0% by weight of the solu- tion. Carbon dioxide is preferably removed to optimize amino- phylline stability by boiling the solution under an inert gas protection. A stabilized aqueous aminophylline solution re- sults which can be packaged in a container system which would otherwise have a propensity to develop undesired crystal growth in the solution. -1-

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