Stabilized anti-hepatitis b (hbv) antibody formulations

Details Stabilized anti-hepatitis b (hbv) antibody formulations Stabilized anti-hepatitis b (hbv) antibody formulations

A - Human Necessities

61

K

A61K 39/42 (2006.01) A61K 39/395 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61P 31/20 (2006.01) C07K 16/00 (2006.01) C07K 16/08 (2006.01)

Patent

CA 2604840

The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.

L'invention concerne des préparations liquides d'anticorps ou de fragments d'anticorps qui se lient spécifiquement avec l'antigène du virus de l'hépatite B (VHB). Cette préparation est stable, présente des niveaux faibles à indétectables d'agrégation, et une perte très faible voire inexistante de l'activité biologique des anticorps ou des fragments d'anticorps, même en cas de stockage prolongé. L'invention concerne en outre des méthodes de prévention, de traitement ou d'amélioration d'un ou de plusieurs symptômes associés à une infection VHB, comprenant l'administration des préparations liquides décrites.

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