A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/42 (2006.01) A61K 39/395 (2006.01) A61P 31/14 (2006.01) C07K 16/10 (2006.01)
Patent
CA 2489534
The present invention provides liquid formulations of antibodies or fragments thereof that immunospecifcally bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. In particular, the present invention provides liquid formulations of antibodies or fragments thereof that immunospecifcally bind to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with RSV infection utilizing the liquid formulations of the present invention.
L'invention concerne des formulations liquides d'anticorps ou de fragments de ceux-ci se liant de façon immunospécifique à un antigène du virus syncytial respiratoire (RSV). Ces formulations possèdent une certaine stabilité, des niveaux faibles à indétectables d'agrégation et très peu ou pas de perte des activités biologiques des anticorps ou des fragments des anticorps, même pendant de longues périodes de stockage. Plus précisément, l'invention concerne des formulations liquides d'anticorps ou de fragments de ceux-ci se liant de façon immunospécifique à un antigène RSV, ces formulations étant sensiblement exemptes de tensioactif, de sels inorganiques et/ou d'autre excipients ordinaires. L'invention concerne enfin des méthodes de prévention, de traitement ou d'amélioration d'un ou de plusieurs symptômes associés à une infection à RSV au moyen des formulations liquides selon l'invention.
Allan Christian B.
Chang Stephen
Oliver Cynthia N.
Medimmune Inc.
Osler Hoskin & Harcourt Llp
LandOfFree
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