Stabilized antibody fragments

Details Stabilized antibody fragments Stabilized antibody fragments

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 1/12 (2006.01) C07K 1/13 (2006.01) G01N 33/534 (2006.01) A61K 38/00 (2006.01) A61K 43/00 (1990.01) A61K 49/02 (1990.01)

Patent

CA 2098097

2098097 9213557 PCTABS00014 Methods for preparing metabolically stable, covalently crosslinked F(ab')2 fragments of antibody molecules for use in labeled form as in vivo diagnostic and therapeutic agents, the stabilized F(ab')2 fragments so produced in free form or conjugated to a chemical moiety, kits containing such fragments, and methods of using these fragments for diagnosis or therapy, are disclosed. In the method, crosslinking is carried out after reduction of inter-heavy chain disulfide bonds, but before cleavage of the crosslinked antibody to produce the F(ab')2 molecules.

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