Stabilized carbapenem antibiotic compositions and method of...

Details Stabilized carbapenem antibiotic compositions and method of... Stabilized carbapenem antibiotic compositions and method of...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/395 (2006.01) C07D 477/02 (2006.01) C07D 477/20 (2006.01)

Patent

CA 2268820

A method is presented for stabilizing carbapenem antibiotics by carboxylating the pyrrolidinyl amino with a carbon dioxide source. The resulting compounds and pharmaceutical compositions thereof can be used in the treatment of infectious diseases, including those resulting from gram positive and negative, aerobic and anaerobic bacteria. The compounds have favorable pharmaceutical properties and stability against .beta.-lactamases, and a favorable duration of action.

Cette invention a trait à une nouvelle forme stabilisée d'antibiotiques à base de carbapenem ainsi qu'à des compositions et à des techniques afférentes. Il est possible d'utiliser ces composés pour le traitement de maladies infectieuses, notamment des maladies provoquées par des bactéries aérobies et anaérobies, à Gram positif et à Gram négatif. Ces composés, qui ont une action bénéfique du point de vue pharmaceutique et qui se révèlent stable face aux bêta-lactamases, ont une durée d'activité notable.

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