Stabilized composition

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4439 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2605839

It is intended to provide a pharmaceutical composition which contains a proton pump inhibitor and is stable even if it is stored for a long time. It is also intended to provide a pharmaceutical composition which contains a proton pump inhibitor susceptible to acid, and does not dissolve in the stomach but dissolves in the intestine to release a primary drug promptly. The object could be achieved by the pharmaceutical composition characterized in that a layer containing a proton pump inhibitor and ethyl cellulose, a layer containing an enteric polymer, and if necessary an intermediate layer composed of one or more layers are formed on a pharmacologically inactive core substance. The intermediate layer is composed of a water-insoluble polymer, a water-soluble polymer, a lubricant and the like.

La présente invention concerne une composition pharmaceutique contenant un inhibiteur de la pompe à proton et étant stable lors d~un stockage à long terme. La présente invention concerne également une composition pharmaceutique contenant un inhibiteur de la pompe à proton susceptible de produire de l~acide et ne se dissolvant pas dans l~estomac, mais dans l~intestin en vue de libérer rapidement un médicament primaire. Le but de la présente invention peut être atteint grâce à la composition pharmaceutique caractérisée en ce qu~une couche contenant un inhibiteur de la pompe à proton et une éthylcellulose, une couche contenant un polymère entérique et, le cas échéant, une couche intermédiaire composée d~une ou plusieurs couches sont formées sur une substance centrale pharmaceutiquement inactive. La couche intermédiaire est composée d~un polymère non hydrosoluble, d~un polymère hydrosoluble, d~un lubrifiant et similaire.

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