A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/592 (2006.01) A61K 31/573 (2006.01) A61K 47/18 (2006.01) A61P 17/06 (2006.01)
Patent
CA 2739376
A storage stable ointment of the present invention comprises a vitamin D compound, a corticosteroid, and an N,N- di(C1-C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester a(C1-C4)-alkyl (C8-C22) carboxylic ester in a petrolatum ointment base, and optionally containing mineral oil and/or tocopherol. Preferably, the vitamin D compound is calcipotriene, the corticosteroid is selected from the group consisting of clobetasol propionate and betamethasone dipropionate, and the N,N-di(C1- C8) alkylamino substituted, (C4-C18) alkyl (C2-C18) carboxylic ester comprises dodecyl 2-(N,N-dimethylamino)-propionate (DDAIP).
Selon la présente invention, un onguent stable lors du stockage comprend un composé de vitamine D, un corticostéroïde, et un ester carboxylique N,N-di (C1-C8) alkylamino substitué, un ester carboxylique (C4-C18) alkyl (C2-C18), un ester carboxylique (C1-C4)-alkyl (C8-C22) dans une base d'onguent de vaseline, et comprend facultativement une huile minérale et/ou du tocophérol. De préférence, le composé de vitamine D est du calcipotriène, le corticostéroïde est choisi dans le groupe comprenant un propionate de clobétasole et un dipropionate de bétaméthasone, et l'ester carboxylique N,N-di(C1-C8) alkylamino substitué, (C4-C18) alkyl (C2-C18) comprend du dodécyle 2-(N,N-diméthylamino)-propionate (DDAIP).
Jo Sung Hi
Pan Jianzhen
Wang Yiping
Wei William Shifeng
Cassan Maclean
Nexmed Holdings Inc.
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